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CLDN18.2 T-cell engager · bispecific antibody

QLS31905

3 active trials, targeting Claudin 18.2 x CD3. Not approved for any biomarker on marked.bio yet.

Counts only trials that select patients by one of the biomarkers on marked.bio, not every trial of this drug.

Biomarkers

BiomarkerActive trialsAll trialsFurthest active phase
Claudin 18.2 expression 3 5 Phase 2

Sponsors

Industry sponsors leading active biomarker-selected trials of QLS31905.

  1. Qilu Pharmaceutical 3

Trials

3 of 5 trials shown

  1. Combination of QLS31905 and Chemotherapy ± QL2107 in Patients With CLDN18.2-positive Advanced Biliary Tract Cancer

    Not yet recruiting Phase 2 Qilu Pharmaceutical Started 2025Primary completion 2026-10 NCT07151872

    QLS31905gemcitabinecisplatinQL2107 Injectionoxaliplatincapecitabine

    Combination of QLS31905 and Chemotherapy ± QL2107 in Patients With CLDN18.2-positive Advanced Biliary Tract Cancer

    Claudin 18.2 expressionCLDN18.2-positive Advanced Biliary Tract Cancer

  2. Combination of QLS31905, QL2107 and Chemotherapy as First-line Therapy in CLDN18.2-positive Unresectable Locally Advanced or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma

    Not yet recruiting Phase 2 Qilu Pharmaceutical Started 2025Primary completion 2026-12 NCT06942767

    QLS31905QL2107 Injectionoxaliplatincapecitabine

    Combination of QLS31905, QL2107 and Chemotherapy as First-line Therapy in CLDN18.2-positive Unresectable Locally Advanced or Metastatic Gastric or Gastroesophageal Junction…

    Claudin 18.2 expressionGastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma

  3. Study of QLS31905 and/or QL1706 Combination With Chemotherapy in the Advanced Malignant Solid Tumors

    Not yet recruiting Phase 2 Qilu Pharmaceutical Started 2024Primary completion 2026-06 NCT06446388

    QLS31905oxaliplatincapecitabinegemcitabinecisplatiniparomlimab and tuvonralimabChemotherapy drug

    Tumor tissue samples determined to be positive for Claudin18.2 by immunohistochemistry (IHC);

    Claudin 18.2 expressionStatus may be outdated, last updated 2024-06-06Advanced Solid Tumor