marked.bio

MET TKI · small molecule

glumetinib

3 active trials across 2 of our biomarkers, targeting MET. Not approved for any biomarker on marked.bio yet.

Also known as SCC244, gumarontinib.

Counts only trials that select patients by one of the biomarkers on marked.bio, not every trial of this drug.

Biomarkers

BiomarkerActive trialsAll trialsFurthest active phase
EGFR exon 19 deletion / L858R 2 3 Phase 2/3
MET exon 14 skipping 1 2 Phase 1/2

Sponsors

Industry sponsors leading active biomarker-selected trials of glumetinib.

  1. Shanghai JMT-Bio 1
  2. Haihe Biopharma 1

Trials

3 of 4 trials shown

  1. Glumetinib Combined With Osimertinib Treatment for Non-Small Cell Lung Cancer Patients

    Not yet recruiting Phase 2/3 Shanghai JMT-Bio Started 2025Primary completion 2028-12 NCT06908772

    glumetinibosimertinib FDA EU

    …ined With Osimertinib as First-Line Treatment in Non-Small Cell Lung Cancer Patients With Classical EGFR Mutations Accompanied by MET Amplification or Overexpression

    EGFR exon 19 deletion / L858RRecurrent or Metastatic NSCLC Patients With Classical EGFR Mutations Accompanied by MET Amplification or Overexpression

  2. Gumarontinib Combined With 3rd EGFR-TKI in Patients With Non-small Cell Lung Cancer.

    Not yet recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences Started 2024Primary completion 2027-12 NCT06452433

    glumetinibosimertinib FDA EUaumolertinibfurmonertinib

    Patients with EGFR mutations known to be associated with drug sensitivity (i.e., exon 19 deletion or L858R mutation).

    EGFR exon 19 deletion / L858RStatus may be outdated, last updated 2024-06-11Non-small Cell Lung Cancer

  3. Assessment of Anti-tumor and Safety in Glumetinib in Patients With c-MET-positive Non-Small Cell Lung Cancer

    Recruiting Phase 1/2 Haihe Biopharma Started 2019Primary completion 2023-10 NCT04270591

    glumetinib

    METex14 skipping mutation who had previously treated by other MET inhibitor(s) or

    MET exon 14 skippingStatus may be outdated, last updated 2022-08-01C-Met Exon 14 Mutation